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84,85 Higher oxidative stress, in conjunction with mitochondrial dysfunction and inflammation, was demonstrated in skin samples from fibromyalgia patients and was correlated with pain

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In the glaucoma-related HTM cell fibrosis model, silybin extensively regulates the expression profiles of coding genes (mRNA) and non-coding RNAs (LncRNA, CircRNA, miRNA), affecting multiple core signaling pathways such as TGF-, PI3K-Akt, and NF-B, and may ultimately achieve the effects of inhibiting extracellular matrix deposition, anti-fibrosis, and regulating inflammatory responses by constructing a ceRNA network ( 8.3 Protective effect against dental inflammation The occurrence and transmission of periodontal diseases are mediated by dysbiosis of the oral microbiota (dental plaque), which then interacts with the hosts immune defenses, leading to inflammation and disease ( in vivo periodontitis models and in vitro LPS-stimulated human periodontal ligament cell (hPDLCs) models, it was found that silybin primarily exerts its core anti-inflammatory effect by downregulating the NF-B and NLRP3 inflammasome signaling axis, thereby effectively inhibiting the expression of key pro-inflammatory cytokines TNF-, IL-1, and IL-6 in the periodontium